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阿尔茨海默病和帕金森病等神经退行性疾病的共同病理特征是Tau和α-Synuclein等蛋白在神经元内异常沉积，形成蛋白聚集体，蛋白聚集体以类似朊蛋白的方式不断扩增，并在神经元之间播散。但迄今为止诱导蛋白聚集的分子机制，以及蛋白聚集体在神经元之间播散的分子机制尚不明确。本团队发现遗传和环境因素可以诱导Tau和α-Synuclein的翻译后修饰，促进其聚集，而突触相关蛋白介导蛋白蛋白聚集体在脑内的播散。

Given that neurotransmitter-dependent neuronal communication provides a basis to realize the function of brain, this organ requires a unique, global and coordinated hydrodynamic system to maintain neurotransmitter homeostasis. In the present study, we characterized a novel aquaporin 4 (AQP4)-dependent fluid regulation system, and developed a set of noninvasive quantitative assessments by MRI...

Largely via epigenomic mechanisms, environmental factors, social stress, and behavior changes are involved in neurological disorders, including neurodegenerative disease, depression, and autism...

癫痫遗传学研究发展迅速，不仅有助于准确病因诊断，也有助于精准医学实践。新发现的癫痫致病基因不断增加，主要涉及离子通道、突触功能、mTOR通路、染色质重塑和转录调控，以及新的体细胞突变基因。结合本课题组的研究，阐述通过患者Trio-WES检测发现新的候选致病基因（germline & somatic），利用细胞/动物模型（包括基因编辑及胚胎电转等）/患者来源的脑组织、iPCS/培养的类脑器官等模型进行致病基因确定及发病机制研究，以及后续转化为精准治疗/新治疗策略的研究。

Recent advances in sequencing technologies promise ultra-long but noisy reads, which requires huge computation resource to calculate pairwise alignment for ultra-long sequence and multiple sequence alignment for correcting the noisy reads...

Organoids are tiny, self-organized 3D tissue cultures that grown from stem cells. These ‘mini-organs’ in a dish can recapitulate key structural and functional properties of human organs. Thus, human organoids provide unique opportunities for the study of human biology...

Dr. Yu will give a talk on identifying associations between the human connectome (i.e., fMRI-based brain networks), AD biomarkers (amyloid-β and tau pathologies measured by PET imaging), transcriptome (measured by brain-wide gene expression data), as well as cognitive changes in AD.

神经接口技术因对失明、耳聋、帕金森、抑郁症等神经系统疾病治疗效果显著而备受关注，但仍面临神经接口核心器件与组织间的界面适配挑战：一方面，由于这类器件往往是二维平面结构，无法在形态上匹配复杂三维组织而影响器件与组织间有效信息交互；另一方面，由于这类器件的表界面细胞亲和性差，会诱发炎症反应导致器件被纤维化组织包裹而丧失信息传递功能。鉴于此，我们提出将刺激形变高分子材料与植入式神经电极复合实现功能化，通过功能电极宏观形状调控，实现电极与生物组织间形态匹配方法；进一步，我们通过功能电极表面微观形貌调控，实现电极与生物组织间良好相容性策略；最后，我们验证新型光电功能电极在神经调控方面的作用。并基于以上研究，探索自适应神经接口器件在神经疾病治疗方面的潜在应用。

he brain functions by integrating sensory information (vision, smell, and touch) with internal states (hunger, fear, aggression) and memory to produce relevant behaviors (eating, fleeing, or fighting). Past studies on neural representations gave us insights into how sensory areas filter complex inputs to retain...