新闻动态

合成生物学通过构建基因线路等一系列手段与工具编辑特定生物行为，实现绿色制造、生物传感等一系列功能。然而，单细胞难以独自完成复杂、多维度及多层次的任务。通过构建菌群并进行精准调控可极大的拓展单菌理论与应用的范围和深度。本报告将介绍报告人近期实验室工作: 通过编辑单细菌乃至菌群实现多层次、多样式的生物智造。

T细胞在适应性免疫应答和炎症性疾病发生中发挥着关键作用。近年新兴的单细胞测序及生物信息计算分析有利于深入了解复杂细胞的类型和功能。主讲人博士研究期间利用单细胞RNA测序与T细胞受体测序技术探索了T细胞亚型的特征并解释其在不同器官和疾病中的功能。通过计算分析结合实验验证，该研究重点探索了组织驻留性记忆T细胞在自身免疫肾炎、慢性肝炎和新冠肺炎中的致病作用。该研究结果揭示了细菌/病毒感染和自身免疫等炎症反应之间的密切关联 为炎症性疾病的治疗干预提供了新的途径。

N-methyl-D-aspartate (NMDA) receptors are glutamate-gated and calcium-permeable ion channels that play critical roles in neuronal development, synaptic plasticity, learning and memory. Dysfunction of NMDA receptors has been implicated in depression, epilepsy, chronic pain, Alzheimer’s disease and autoimmune encephalitis...

In his talk, Dr. Wang will present the Allen Mouse Brain Common Coordinate Framework (CCFv3) as such a resource.

The cytoplasm of a cell is crowded with different kinds of macromolecules. A cell can have more than 1 million protein molecules and hundreds of RNA molecules per μm3. Optical imaging offers very high molecular sensitivity and specificity but can be limited in its multi-color imaging capability and by optical crowding when studying complex molecular organization...