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In the coming 30 years, the proportion of the world's population over 60 years old will nearly double. One of the most impactful social and economic consequences of aging is the decline of cognitive functions and associated neurodegenerative diseases. In most of the neurodegenerative diseases, aberrant accumulation of protein aggregates occurs and is closely related with disease progression...

Multi-modal omics is an approach gaining popularity in modern neuroscience research. With the great advances in high-throughput technologies, large-scale omics data begin to lay foundations for a comprehensive understanding of the brain...

The canonical model of striatal function predicts that animal locomotion is associated with the opposing regulation of protein kinase A (PKA) in direct and indirect pathway striatal spiny projection neurons (SPNs) by dopamine. However, the precise dynamics of PKA in dorsolateral SPNs during locomotion remain to be determined. It is also unclear whether other neuromodulators are involved...

This talk addresses flexible materials and device engineering toward skin-integrated electronics and implantable neural interfaces. We first introduce ultraflexible organic optoelectronics functioning as sensing components and energy harvesters as wearables. We then demonstrate a highly conductive tattoo electrode that can be placed on the skin or injected into the epidermis layer for real-time and precise electrophysiological signal recordings...

Cytokines are signalling molecules between cells in immune system with important implications in diseases diagnosis and management. Cytokine storm in COVID-19 results from a sudden acute increase in circulating levels of different pro-inflammatory cytokines and can cause several disease and major-organ injury. Thus, there is urgent need to develop rapid, sensitive, and specific methods for monitoring of cytokines in biology and medicine...

自2012年斯坦福大学Brian Kobilka 教授获得诺贝尔化学奖以来，G蛋白偶联受体的结构生物学领域进入了蓬勃发展的黄金年代。一系列作为重要药物靶点相关受体的高分辨率结构得到解析，并且近年来冷冻电镜技术更是推动了此领域的快速发展。同时，基于结构的药物设计也展示出巨大的价值推动相关的开发转化工作。杜教授将从个人的研究方向简要介绍下近来取得的研究进展，以及这些基础或转化研究对药物发现的启示。

任庆仲博士现任Cell Press旗下Cell Reports期刊科学编辑。在中国科学院神经科学研究所获得博士学位后，于美国霍华德休斯医学研究院下属珍妮莉亚研究园区从事博士后研究，2019年7月赴西雅图艾伦研究所任职Scientist。2021年加入Cell出版社。

易陈菊 (PhD，MD)，独立PI，副研究员，博士生导师。华中科技大学同济医学院临床六年制德语班（学士），华中科技大学同济医院神经内科硕博连读（PhD），德国图宾根大学(Eberhard Karls Universität Tübingen)医学院医学博士（MD）。法国巴黎法兰西学院 (Collège de France)、法国科学院博士后(合作导师：神经胶质细胞领军人物Christian Giaume教授)，新加坡国立大学生命研究中心Senior Research Fellow(合作导师：诺贝尔议会成员、诺贝尔生理学/医学奖评委会委员Carlos Ibanez教授)。主要从事神经胶质细胞在中枢神经系统疾病中的作用机制研究，在神经科学杂志发表SCI论文50余篇，其中以一作/通讯在Neuron、Brain、The EMBO Journal、Advanced Science、Annals of Neurology、Glia等发表26篇。

动脉粥样硬化在多个部位发生，以往认为是共同危险因素所致。我们最新的研究发现，动脉粥样硬化可通过外泌体从一个部位转移到另一个部位，就如同肿瘤的血运转移一样。

From tropical forests to gut microbiomes, ecological communities host striking numbers of coexisting species. Beyond high biodiversity, communities exhibit a range of complex dynamics that are difficult to explain under a unified framework. Using bacterial microcosms, we perform the first direct test of theory predicting that simple coarse-grained features dictate emergent behaviors of communities...